Most Mac users who use the native Notes app ask "can the default font size for the Apple native Notes app be changed?" Well, the short answer is 'No'. HOWEVER, there is a small work around to give you a larger font size using the infamous 'Control +' keys shortcut when writing a Note:
1. Open a new Note, and before starting your Note ...
2. Hit the Control key and the + key simultaneously - at least 3 times
3. Now, write your Note
4. Important: you MUST increase the font size BEFORE writing Note - Done!